A living, curated map of how AI is transforming the design and discovery of therapeutically and commercially relevant biomolecules: proteins, antibodies, mRNA, enzymes, and the foundation models behind them.
Iso-AF folds protein–RNA complexes end-to-end. Beats diffusion baselines on PDB-Held-Out by 14% mean-pLDDT, with usable accuracy on previously unannotated riboswitches.
All-atom diffusion samples binders against three GPCR targets. 32% of designs show µM affinity in SPR; 4 candidates progress to crystallography.
Largest released checkpoint shows non-linear gains on EC-number prediction without fine-tuning. Public access via API; weights restricted to academic.
New release jointly optimizes codon usage and 5′/3′ UTR secondary structure for expression × stability. Reproduces a published vaccine candidate to within 6% of empirical yield.
Agent plans, dispatches, and revises directed-evolution rounds via the Emerald Cloud API. Reports 3.4× improvement over manual baseline; failure modes analyzed in detail.
Conditional diffusion over sequence space, anchored to a Tm regressor. 18/24 designed variants surpass parent ΔTm > 8°C with retained activity.
INS018_055, designed via a generative + reinforcement pipeline, enters Phase 2a with 60 patients enrolled. First fully AI-designed Phase 2 candidate disclosed in IPF.
Arc Institute releases sequence-only foundation model trained on metagenomic corpus. Strong zero-shot DMS performance; weights and training pipeline open.
Foundation Models for Biology (the architectural shift underlying everything else)
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Drug Discovery (Small Molecules)
Cellular & Systems Modeling ("Virtual Cells")
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15 tracked tools across this domain. Click through for the subdomain breakdown.
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